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Finding treatments

finding_treatments.pngClues for treating a disease can sometimes be gleaned by observing how normal tissues and cells behave. Harvard NeuroDiscovery Center scientists are teaming up to study a group of cells in developing mouse brains that may hold clues for better therapies for neurodegenerative diseases.

“Progenitor” cells give rise to all nerve cells in the brain during embryonic development. It is possible that these cells — present in small numbers in adult brains but abundant in embryos — may be somehow coaxed into replacing cells that are damaged or lost to the ravages of Alzheimer’s, Parkinson’s, or other neurodegenerative diseases.

Researchers from Christopher Walsh’s lab at Harvard Medical School used a high power microscope and other resources at the Harvard NeuroDiscovery Center’s imaging facility. The aim was to closely examine how progenitor cells in the brains of mouse embryos divide and differentiate into mature nerve cells.


Advance the cause

Neurodegenerative diseases take a huge toll on individual patients, their families and the community. Already millions cope with the physical, emotional, and financial effects of neurodegenerative diseases. Many more individuals and their families will be affected by these diseases as our population continues to age.

Sadly, many neurodegenerative diseases receive minimal attention from the biotechnology and pharmaceutical industries.  The sheer complexity of these diseases, the perception that individual neurodegenerative diseases represent a relatively small market opportunity and industry's waning appetite for early-stage biomedical research have resulted in a worrying decline in the number of new treatments for neurodegenerative disease.  

While academia continues to make excellent progress on understanding how neurodegenerative diseases develop, we can not rely on traditional academic researchers to design meaningful treatments for patients.  Academic scientists simply to do not have the required resources nor support to develop real interventions for patients. 

To be successful in this challenging environment, we must build new partnerships and programs that specifically address the need to translate university research into viable patient interventions. To strengthen this pioneering biomedical research endeavor, we need the support of others who share our desire for a new approach to tackling these diseases.

If you share our vision of a world without neurodegenerative diseases and — like us — are serious about making a difference, please join us.  The Harvard NeuroDiscovery Center offers the best investment — and hope for progress — for visionary philanthropists looking to beat these devastating diseases.