LDDN Postdoctoral Sabbatical Program In Drug Discovery Awardees
The Harvard NeuroDiscovery Center's Laboratory for Drug Discovery in Neurodegeneration is pleased to announce the annual awardees for the Postdoctoral Sabbatical Program:
AY09 - NCDDN Fellows
Dimitri Krainc (Harvard Medical School/Brigham and Women's Hospital) — PGC-1alpha Transcriptional Assay
David Ron (New York University) — Inhibition of Sulfhydryl Oxidases to Control Oxidative Stress
Haining Zhu (University of Kentucky) — Abrogating interaction between Mutant SOD I and Dynein: A Novel ALS Therapeutic Strategy
Colin Combs (University of North Dakota) — Inhibition of lyn kinase to attenuate oligomer-stimulated microglial activation in Alzheimer's disease
Carmela Abraham (Boston University) — Screen for small compounds the inhibit APP dimerization and Abeta generation
AY08 - NCDDN Fellows
Jeremy Hwang, Mentor Tae-Wan Kim (Columbia University) — Modulators of BACE1-mediated APP cleavage
Kent Matlack, Mentor Susan Lindquist (Whitehead Institute) — Yeast drug discovery platforms for protein misfolding
Yang Zhang, Mentor Paul Lombroso (Yale University) — Screening for Inhibitors for STEP
Heechul Kim, Mentor Hoon Ryu (Boston University) — Targeting of BRCA1 in Neuronal DNA Damage Response
Shibu Poulose, Mentor Zhenyu Yue (Mount Sinai School of Medicine) — Inhibitors of kinase/GTPase activities of the brain Lrrk2
AY07 - NCDDN Fellows
Sang-Jun Jeon, Mentor Albert Edge (Massachusetts Eye and Ear Infirmary) — A Screen for Atoh1 Activation
Melissa Sarantos, Mentor Robert Hughes (Buck Institute) — Specific Translational Inhibition of Mutant Htt
Craig Colton, Mentor Chien-Liang (Ohio State University) — Stimulation of glial Glutamate transporter EAAT2 expression
Wensheng Lin, Mentor Brian Popko (University of Chicago) — Activators of the PERK Pathway
Segal, Mentor Benjamin Wolozin (Boston University) — Identification of Functional Inhibitors of LRRK2
AY06 - NCDDN Fellows
Kathleen Seyb, PhD, Mentor Mary Michaelis, PhD (University of Kansas) - Inhibitors of Abeta induced calpain activation
Tommy Gainer, PhD, Mentor Donald Lo (Duke University) — Inhibitors of EphB3 kinase
Imelda Pepivani, PhD, Mentor Michael Schlossmacher (Brigham and Women's Hospital) — Modulators of the Expression of the Parkin Gene
Carl Sunshine, PhD, Mentor Steve Finkbeiner (University of California, San Francisco) — Modulation of Akt kinase
Luisa Quinti, PhD, Mentor Steve Finkbeiner (University of California, San Francisco) — Inhibition of toxic conformation isomerization of polyQ
AY05
Greg Korbel, PhD, Mentor Hidde L. Ploegh, PhD (Harvard Medical School) — High-throughput screening for neuroprotective small molecule modulation in Huntington's disease and chemistry-based target identification
Anatolii Kabakov, PhD, Mentor Paul Rosenberg, MD, PhD (Children's Hospital) — Discovery of modulators of glutamate transport in the central nervous system
Ana George, PhD, Mentor Richard E. Fine, PhD (Boston University) — Library screen for drugs that increase IDE in cerebrovasculature
AY04
Hanspeter Waldner, PhD (Brigham and Women's Hospital) — Identifying drug-like molecules that modulate Th1/Th2 cytokine production in myelin-reactive T cells
AY03
Jae Suk Ahn, PhD, Mentor Kenneth S. Kosik, MD (Brigham and Women's Hospital) — Development of high-throughtput assays to screen for inhibitors of tau
Pancham Bakshi, PhD, Mentor Michael Wolfe, PhD (Brigham and Women's Hospital) — A high-throughput screen to identify modulators of amyloid beta precursor protein processing
Xiaoyan Sun, MD, PhD, Mentor Jie Shen, PhD (Brigham and Women's Hospital) — Screen compounds that are differentially toxic to parkin knockout neurons
Tasneem Zahir, PhD, Mentor Michael Young, PhD (Schepens Eye Research Institute) — Identification of small molecules that promote differentiation of stem cells
Melissa Joy Nicholson, PhD, Mentor Kai Wucherpfennig, MD, PhD (Dana-Farber Cancer Institute/Harvard Medical School) — Inhibition of antigen presentation in multiple sclerosis
AY02
David Wilson, PhD, Mentor Clifford B. Saper, MD, PhD (Beth Israel Deaconess Medical Center) — Polymerization of full length tau
Craig Justman, PhD, Mentor Peter Lansbury, PhD (Brigham and Women's Hospital) — Oligomerization of synuclein
June-Young Park, PhD, Mentor Peter Lansbury, PhD (Brigham and Women's Hospital) — UCH-L1 expression
Hilal Lashuel, PhD, Mentor Peter Lansbury, PhD (Brigham and Women's Hospital) — UCH-L1 activity
Sunny Sarang, PhD, Mentor Steven R. Gullans, PhD (Brigham and Women's Hospital) — alpha-Synuclein expression
Jin Wang, PhD, Mentor James F. Gusella, PhD (Massachusetts General Hospital) — PolyGlu aggregation
Pierre-Francois Pradat, PhD, Mentor Robert H. Brown, MD, PhD (Massachusetts General Hospital) — SOD activity