LDDN Projects

Project

Project Status

1

2

3

4

5

6

7

1

Inhibitors of cdk5/p25-Catalyzed Phosphorylation of Tau

 X

 X

 X

 X

 X

X

X

2

Activators of Peptide-Exchange on MHC II

X

X

X

X

X

X

X

3

Inhibitors of EphB3 Kinase (Yr1)^a

X

X

X

X

X

X

X

4

Expression of Survival Motor Neuron (SMN)

X

X

X

X

X

X

X

5

Activation of Glu Transporter EAAT2 Expression (Yr2)

X

X

X

X

X

X

X

6

Activators of Atoh1 (Yr2)

X

X

X

X

X

X

7

Inhibition of STEP (Yr3)

X

X

X

X

X

X

 X

8

Inhibition of BACE1 in Neuronal Cells (Yr3)

X

X

X

X

X

X

9

Inhibition of Kinase & GTPase Activities of LRRK2 (Yr3)

X

X

X

X

 X

10

Enhancers of Expression of BRCA1 (Yr3)

X

X

X

X

X

11

Activators of Klotho 

X

 X

 X

 X

12

Inhibition of Interaction between mSOD1 and Dynein (Yr4)

X

13

Inhibition of Ero1 Sulfhydryl Oxidase (Yr4)

X

X

X

X

14

Activators of PGC-1a (Yr4)

X

X

X

X

  15

Inhibition of Lyn Kinase (Yr4)

 X

  16

Inhibitors of APP dimerization (Yr4)

 X

  17

Stimulation of Microglia Generation (CADDI^b)

 X

  18

Inhibition of TDP-43 Generation (CADDI)

 X

19

Modulators of the Expression of B-Synuclein

dormant^c

20

Modulators of Insulin-Degrading Enzyme

  21

Modulators of UCH-L1 Activity

  22

Inhibitors of Tissue Transglutaminase

  23

Inhibitors of Processing of Amyloid-B Precursor

  24

Necrosis Inhibitors

         licensed IP