Member publications
This is the Harvard NeuroDiscovery archive of scientific publications from 2007, 2008 and 2009, authored by members of our community. The publications posted here were supported at least in part by the Harvard NeuroDiscovery Center. For publications from 2001 to 2006, please click on publication year to the left.
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*Published with acknowledgment of Harvard Neurodiscovery Center (formerly the Harvard Center for Neurodegeneration & Repair or "HCNR") resources.
2009
Xu L, di Tomaso E, Duda DG, Ancukiewicz M, Chung DC, Lauwers GY, Shellito P, Poleski M, Bentley R, Czito BG, Clark JW, Willett CG, and Jain RK. "Direct evidence that anti-VEGF therapy upregulates inflammatory pathways and neuropilin 1." Submitted. 2009
February
Kwiatkowski TJ Jr., Bosco D, LeClerc AL, Tamrazian E, Vanderburg CR,
Russ C, Davis A, Gilchrist J, Kasarskis E, Munsat T, Rouleau G, Hosler
B, Haines J, Pericak-Vance M, Siddique T, McKenna-Yasek D, Sapp, PC ,
Horvitz HR, Landers JE, Brown RH, Jr. "Mutations in the FUS/TLS Gene in Chromosome-16-Linked Familial Amyotrophic Lateral Sclerosis." Science 2009. In press.
January
Kong W, Mou X, Liu Q, Chen Z, Vanderburg CR, Rogers JT, Huang X. January 28, 2009. "Independent component analysis of Alzheimer's DNA microarray gene expression data." Molecular Neurodegeneration 2009, 4:5.
2008
December
Cuny G, Degterev A, Yuan K. "Necroptosis - a novel cell death mechanism." Drugs of the Future 2008, 33(2).
November
Yu P.B, Deng D.Y, Lai C.S, Hong C.C, Cuny G.D, Bouxsein M.L, Peterson R.T, Katagiri T, Fukuda T, Mishina Y, Bloch K.D. “BMP type I receptor inhibition reduces heterotopic ossification” Nature Medicine 2008, 14, 1363 – 1369. Electronically published November 31, 2008.*
Laha J, Cuny G. "Synthesis of Tetrazolo[1,5-a]pyridines Utilizing Trimethylsilyl Azide and Tetrabutylammonium Fluoride Hydrate" Synthesis 2008, No. 24, pp 4002–4006. Electronically published November 14 2008.*
Kong W, Vanderburg C, Gunshin H, Rogers J, Huang X. "Independent component analysis of Alzheimer's DNA microarray gene expression data." BioTechniques 2008, Volume 45, pages 501-520.
Ferland R, Batiz LF, Neal J, Lian G, Bundock E, Lu J, Hsiao YC, Diamond R, Mei D, Banham A, Brown PJ, Vanderburg CR, Joseph J, Hecht J, Folkerth R, Guerrini R, Walsh CA, Rodriguez E, Sheen V. "Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopias." Human Molecular Genetics 2008, 18: 497-516. Published November 5, 2008. Electronically published February, 2009.*
October
Patnaik D, Jun X, Glicksman MA, Cuny GD, Stein RL, Higgins JM. "Identification of small molecule inhibitors of the mitotic kinase haspin by high-throughput screening using a homogeneous time-resolved fluorescence resonance energy transfer assay." Journal of Biomolecular Screening 2008, 13; 1025. Electronically Published October 31, 2008.*
August
Wagle N, Xian J, Shishova E.Y, Wei J, Glicksman M.A, Cuny G.D, Stein R.L, Cohen D.E. "Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screening" Analytical Biochemistry 2008, 383 (2008) 85–92. Electronically published August 12, 2008.*
Scherzer CR, Grass JA, Liao Z, Zheng B, Pepivani I, Eklund AC, Ney PA, Ng J, McGoldrick M, Moellenhauer B, Bresnick EH, Schlossmacher MG . "GATA transcription factors directly regulate the Parkinson's disease linked gene alpha-synuclein." Proceedings of the National Academy of Sciences 2008, U.S.A,105, 10907-10912. Electronically published August 5, 2008.*
July
R. Liu M, Choi S, Cuny G, Ding K, Dobson B, Glicksman M, Auerbach K, and Stein. "Kinetic Studies of Cdk5/p25 Kinase: Phosphorylation of Tau and Complex Inhibition by Two Prototype Inhibitors." Biochemistry 2008, 47 (32), 8367-8377. Electronically published July 18, 2008.*
Qazi AA, Radmanesh A, O'Donnell L, Kindlmann G, Peled S, Whalen S, Westin CF, Golby AJ."Resolving Crossing in the Corticospinal Tract by Two-tensor Steamline Tractography: Method and Clinical Assessment Using fMRI." NeuroImage 2008. Electronically published July 8, 2008.*
June
Laha J.K, Xing X, Liu J.-F, Lai C.S, Deng D.Y, Sachidanandan C, Bloch K. D, Peterson R.T.“Structure activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors.” Bioorganic and Medicinal Chemistry Letters 2008. Electronically published June 27, 2008.*
May
Tie Y, Whalen S, Suarez RO, Golby AJ. September 1, 2008."Group Independent Component Analysis of Language fMRI From Word Generation Tasts." NeuroImage 2008. Electronically published May 29, 2008.*
You Z, Savitz S, Yang J, Degterev A, Yuan J, Cuny G, Moskowitz M, Whalen M "Necrostatin-1 Reduces Histopathology and Improves Functional Outcome After Controlled Cortical Impact in Mice." Journal of Cerebral Blood Flow & Metabolism 2008, 28, 1564–1573. Electronically published May 21 2008.*
April
Teng X, Keys H, Yuan J, Degterev A, Cuny GD. "Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors." Bioorganic & Medicinal Chemistry Letters 2008. Electronically published April 25, 2008.*
Degterev A, Hitomi J, Germsheid M, Ch’en I, Korkina O, Teng X, Abbott D, Cuny G.D, Yuan C, Wagner G, Hedrick S.M, Gerber S.A, Lugovskoy A, Yuan J. “Identification of RIP1 kinase as a specific cellular target of necrostatins.” Nature Chemical Biology 2008. Electronically Published April 13, 2008.*
March
Arboleda-Velasquez J, Zhou Z, Shin HK, Louvi A, Kim HH, Savitz S, Liao J, Salomone S, Ayata C, Moskowitz M, and Artavanis-Tsakonas S. March 25, 2008. "Linking Notch Signaling to Ischemic Stroke." Proceedings of the National Academy of Science 2008, USA 105(12): 4856–4861.
February
Miller SL, Celone K, Depeau K, Diamond E, Dickerson BC, Rentz D, Pihlajamäki M, Sperling RA. February 12, 2008. "Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation." Proceedings of the National Academy of Sciences 2008, USA 105(6): 2181-6. Electronically published January 31, 2008.*
January
Spires-Jones T, de Calignon A, Matsui T, Zehr C, Pitstick R, Wu HY, Osetek J, Jones P, Bacskai B, Feany M, Carlson G, Ashe K, Lewis J, Hyman B. January 23, 2008. "In Vivo Imaging Reveals Dissociation between Caspase Activation and Acute Neuronal Death in Tangle-Bearing Neurons." The Journal of Neuroscience 2008, 28(4):862–867.
Wang M, Zhou X, Li F, Huckins J, King RW, Wong ST. January 1, 2008. "Novel cell segmentation and online SVM for cell cycle phase identification in automated microscopy." Bioinformatics 2008, 24(1): 94-101. Electronically published November 7, 2007.*
Wang J, Zhou X, Bradley PL, Chang SF, Perrimon N, Wong ST. January 2008. "Cellular phenotype recognition for high-content RNA interference genome-wide screening." Journal of Biomolecular Screening 2008, 13(1): 29-39.*
2007
December
O'Donnell LJ, Westin CF, Golby AJ. "Tract-Based Morphometry." MICCA. Electronically published 2007.
Teng X, Keys H, Jeevanandam A, Porco JA Jr, Degterev A, Yuan J, Cuny GD. "Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors." Bioorganic & Medicinal Chemistry Letters 2007, 17(24): 6836-40. December 15, 2007. Electronically published October 17, 2007.*
Stein RL. "A new model for academics based drug discovery." Current Alzheimer Research 2007, 4(5): 574-6.* December 2007
Glicksman MA, Cuny GD, Liu M, Dobson B, Auerbach K, Stein RL, Kosik KS. . "New approaches to the discovery of cdk5 inhibitors." Current Alzheimer Research 2007, 4(5): 547-9. December 2007*
November
Peled S. "New perspectives on the sources of white matter DTI signal." IEEE Transactions on Medical Imaging 2007, 26(11):1448-55. November 2007.*
September
Seng S, Avraham H, Li H, Jiang S, Avraham S. "The Nuclear Matrix Protein, NRP/B, Enhances Nrf2-Mediated Oxidative Stress Responses in Breast Cancer Cells." Cancer Research 2007, 67(18): 8596-604. September 15, 2007.
Li G, Liu T, Tarokh A, Nie J, Guo L, Mara A, Holley S, Wong ST. "3D cell nuclei segmentation based on gradient flow tracking." BMC Cell Biology 2007, 8:40. September 4, 2007.*
Srinivasan R, Zhou X, Miller E, Lu J, Litchman J, Wong ST. "Automated axon tracking of 3D confocal laser scanning microscopy images using guided probabilistic region merging." Neuroinformatics 2007, 5(3): 189-203. Fall 2007.*
August
The International Multiple Sclerosis Genetics Consortium. "Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study." New England Journal of Medicine 2007. August 30, 2007. Electronically published July 29, 2007.*
Chung CY, Koprich JB, Endo S, Isacson O. "An Endogenous Serine/Threonine Protein Phosphatase Inhibitor, G-Substance, Reduces vulnerability in Models of Parkinson's Disease." Journal of Neuroscience 2007, 27(31): 8314-23. August 1, 2007.*
July
Liu B-F, Liang J. "Protein-protein interactions among human lens acidic and basic B-crystallins." FEBS Letters 2007, 581: 3936-42. July 23, 2007.*
Pack-Chung, Eunju. "A Drosophila kinesin required for synaptic bouton formation and synaptic vesicle transport." Nature Neuroscience 2007, 10: 980-989. July 22, 2007.*
Alvarez VA, Ridenour DA, Sabatini BL. "Distinct Structural and Ionotropic Roles of NMDA Receptors in Controlling Spine and Synapse Stability." The Journal of Neuroscience 2007, 27(28): 7364-76. July 11, 2007.*
Mermerian AH, Case A, Stein RL, Cuny GD. "Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors." Bioorganic & Medicinal Chemistry Letters 2007, 17(13): 3729-32. July 1, 2007. Electronically published April 10, 2007.*
June
Liu B-F, Anbarasu K, Liang J. "Confocal fluorescence resonance energy transfer microscopy study of protein-protein interactions of lens crystallins in living cells." Molecular Vision 2007, 13: 854-61. June 14, 2007.*
Lee TH, Seng S, Sekine M, Hinton C, Fu Y, Avraham H, Avraham S. "Vascular Endothelial Growth Factor Mediates Intracrine Survival in Human Breast Carcinoma Cells through Internally Expressed VEGFR1/FLT1." PLoS Medine 2007, 4(6): e186. June 5, 2007.
April
Jiang S, Seng S, Avraham H, Kim T, and Avraham S. "Process Elongation of Oligodendrocytes is promoted by the Kelch-related Protein MRP2/KLHL1." Journal of Biological Chemistry 2007, 282(16): 12319-29. April 20, 2007.
Jagtap PG, Degterev A, Choi S, Keys H, Yuan J, Cuny GD. "Structure-Activity Relationship Study of Tricyclic Necroptosis Inhibitors." Journal of Medicinal Chemistry 2007, 50(8): 1886-95. April 19, 2007. Electonically published March 16, 2007.*
March
Certel SJ, Savella MG, Schlegel DC, Kravitz EA. "Modulation of Drosophila male behavioral choice." Proceedings of the National Academy of Sciences, USA 2007, 104(11): 4706-11. March 13, 2007.*
Khoury JE, Toft M, Hickman SE, Means TK, Terada K, Geula C, Luster AD. 2007. "Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease." Nature Medicine. Electronically published March 11, 2007.*
The International Multiple Sclerosis Genetics Consortium. "A second major histocompatibility complex susceptibility locus for multiple sclerosis." Annals of Neurology 2007, 61(3): 228-36. March 2007. Electronically published January 24, 2007.*
January
Case A, Stein RL. "Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic slow-binding inhibitor." Biochemistry 2007, 46(4): 1106-15. January 30, 2007.*