2004 - 2003 Publications Archive

*Published with acknowledgment of Harvard Neurodiscovery Center (formerly the Harvard Center for Neurodegeneration & Repair or "HCNR") resources.

2004

December

Corey DP, Garcia-Anoveros J, Holt JR, Kwan KY, Lin SY, Vollrath MA, Amalfitano A, Cheung ELM, Derfler BH, Duggan A, Geleoc GSG, Gray PA, Hoffman MP, Rehm HL, Tamasauskas ED, Zhang DS. December 9, 2004. "TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells." Nature 432: 723-30.

Ahn JS, Muscaccio A, Mapelli M, Ni J, Scinto L, Stein R, Kosik KS, Yeh LA. 2004. "Development of an assay to screen for inhibitors of tau phosphorylation by Cdk5." Journal of Biomolecular Screening 9: 122-31.*

October

Shu T, Ayala R, Nguyen MD, Xie Z, Gleeson JG, Tsai1 LH. October 14, 2004. "Ndel1 Operates in a Common Pathway with LIS1 and Cytoplasmic Dynein to Regulate Cortical Neuronal Positioning." Neuron 44: 263–77.

Cooper O, Isacson O. October 13, 2004. "Intrastriatal Transforming Growth Factor Delivery to a Model of Parkinson's Disease Induces Proliferation and Migration of Endogenous Adult Nerual Progenitor Cells without Differentiation into Dopaminergic Neurons." Neurobiology of Disease 24(41): 8924-31.*

Bertram L, Tanzi RT. October 2004. "The current status of Alzheimer’s disease genetics: what do we tell the patients?" Pharmacological Research 50(2004): 385-96.*

Fox JH, Barber DS, Singh B, Zucker B, Swindell MK, Norflus F, Buzescu R, Chopra R, Ferrante RJ, Kazantsev A, Hersch SM. October 2004. "Cystamine increases L-cysteine levels in Huntington's disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation." Journal of Neurochemistry 91(2): 413-22.*

September

Choi S, Haggart D, Toll L, Cuny GD. September 6, 2004. "Synthesis, receptor binding and functional studies of mesoridazine stereoisomers." Bioorganic & Medicinal Chemistry Letters 14(17): 4379-82.*

Zhang M, Zhang H, Tjandra D, Wong STC. September 2004. "DBMap: A space-conscious data visualization and knowledge discovery framework for biomedical data warehouse." IEEE Trans Information Technologies in Biomedicine 8(3): 343-53.*

August

Scherzer CR, Offe K, Gearing M, Rees HD. Fang G, Heilman CJ, Schaller C, Bujo H, Levey AI, Lah JJ. August 2004. "Loss of Apolipoprotein E Receptor LR11 in Alzheimer Disease." Archives of Neurology 61(8): 1200-5.*

Zhou X, Liu K L, and Wong STC. August 2004. "Cancer classification and prediction based on logistic regression using approximate Bayesian gene selection." Journal of Biomedical Informatics 37: 249-59.*

Inoue R, Moghaddam KA, Ranasinghe M, Saeki Y, Chiocca EA, Wade-Martins R. August 2004. “Infectious delivery of the 132 kb CDKN2A/CDKN2B genomic DNA region results in correctly spliced gene expression and growth suppression in glioma cells.” Gene Therapy 11: 1195–204.

July

Xie J, Zhu H, Larade K, Ladoux A, Seguritan A, Chu M, Ito S, Bronson RT, Leiter EH, Zhang CY, Rosen ED, Bunn HF. July 20, 2004. "Absence of a reductase, NCB5OR, causes insulin-deficient diabetes." Proceedings of the National Academy of Sciences, USA 101(29): 10750-5.

The International Multiple Sclerosis Genetics Consortium. July 6, 2004. "Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping." Human Molecular Genetics 13(17): 1943-9.*

Scherzer CR, Feany MB. July 2004. "Yeast genetics targets lipids in Parkinson's disease." TRENDS in Genetics 20: 273-7.*

Lansbury PT. July 2004. "Back to the future: the 'old-fashioned' way to new medications for neurodegeneration." Nature Reviews Neuroscience 10(Suppl): S51-7. Published online July 1, 2004.*

May

Ray SS, Nowak RJ, Strokovich K, Brown RH, Walz T, Lansbury PT. May 4, 2004. "An Intersubunit Disulfide Bond Prevents in Vitro Aggregation of a Superoxide Dismutase-1 Mutant Linked to Familial Amyotrophic Lateral Sclerosis." Biochemistry 43(17): 4899-905.

April

Saura CA, Choi SY, Beglopoulos V, Malkani S, Zhang D, Rao BSS, Chattarji S, Kelleher III RJ, Kandel ER, Duff K, Kirkwood A, Shen J. April 8, 2004. "Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-Dependent Neurodegeneration." Neuron 42: 23-36.

Palacino JJ, Sagi D, Goldberg MS, Krauss S, Motz C, Wacker M, Klose J, Shen J. April 2004. "Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice." Journal Biolgical Chemistry 279: 18614-22.*

Bertram L, Parkinson M, Mullin M, Menon R, Blacker D, Tanzi RE. April 2004. "No association between a previously reported OLR1 3' UTR polymorphism and Alzheimer's disease in a large family sample." Letter to Journal of Medical Genetics 41(4): 286-8.*

Bertram L, Tanzi RE. April 2004. "Alzheimer's disease: one disorder, too many genes?" Human Molecular Genetics 13: 135-41.*

Farris W, Mansourian S, Leissring MA, Eckman EA, Bertram L, Eckman CB, Tanzi, RE, Selkoe DJ. April 2004. “Partial loss-of–function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid ß-protein.” American Journal of Pathology 164: 1425-34.

March

Hemelaar J, Galardy PJ, Borodovsky A, Kessler BM, Ploegh HL, Ovaa H. March-April 2004. "Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases." Journal of Proteome Research 3(2): 268-76.*

Young TL, Cepko CL. March 25, 2004. "A role for ligand-gated ion channels in rod photoreceptor development." Neuron 41: 867-79.*

Wong STC, Hoo KS, Cao X, Tjandra D, Fu JC, Dillon WP. March 2004. "A neuroinformatics database system for disease-oriented neuroimaging research." Academic Radiology 11: 345-58.*

February

Magrane J, Smith RC, Walsh K, Querfurth HW. February 18, 2004. "Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-Amyloid in neurons." Journal of Neuroscience 24: 1700-6.*

Ovaa H, Kessler BM, Rolen U, Galardy PJ, Ploegh HJ, Masucci MG. February 2004 "Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells." Proceedings of the National Academy of Sciences, USA 101(8): 2253-8.*

January

Bertram L, Menon R, Mullin K, Parkinson M, Bradley ML, Blacker D, Tanzi RE. January 27, 2004. "PEN2 is not a genetic risk factor for Alzheimer's disease in a large family sample." Neurology 62: 304-6.*

Hengge AC, Stein RL. January 27, 2004. "Role of protein conformational mobility in enzyme catalysis: acylation of alpha-chymotrypsin by specific peptide substrates." Biochemistry 43(3): 742-7.*

Wang Y, Bruckner R, Stein RL. January 13, 2004. "Regulation of signal peptidase by phospholipids in membrane: characterization of phospholipid bilayer incorporated Escherichia coli signal peptidase." Biochemistry 43(1): 265-70.*

Matsuda T, Cepko CL. January 6, 2004. "Electroporation and RNA interference in the rodent retina in vivo and in vitro." Proceedings of the National Academy of Sciences, USA 101: 1.*

Slaugenhaupt SA, Mull J, Leyne M, Cuajungco MP, Gill SP, Hims M, Quintero F, Axelrod FB, Gusella JF. January 6, 2004. "Rescue of a human mRNA splicing defect by the plant cytokinin kinetin." Human Molecular Genetics 13: 4.*

Emelaar J, Borodovsky A, Kessler BM, Reverrter D, Cook J, Kolli N, Gan-Erdene T, Wilkinson KD, Gill G, Lima CD, Ploegh HL, Ovaa H. January 2004. "Specific and Covalent Targeting of Conjugating and Deconjugating Enzymes of Ubiquitin-Like Proteins." Molecular and Cellular Biology 84-95.*

Wong STC, Cao X, Hoo KS, Tjandra D, Foo JC, Lowenstein DH. 2004. "A Web-Based Federated Neuroinformatics Model for Surgical Planning and Clinical Research Applications in Epilepsy." Neuroinformatics 2(1): 101-18.*

Ancuta P, Moses A, Gabuzda D. 2004. "Transendothelial migration of CD16+ monocytes in response to fractalkine under constitutive and inflammatory conditions." Immunobiology 209(1-2): 11-20.

2003

December

McQueen MB, Bertram L, Rimm EB, Blacker D, Santangelo SL. December 31, 2003. "A QTL genome scan of the metabolic syndrome and its component traits." BMC Genetics 2003 4(Suppl 1): S96.*

Hemelaar J, Leyveld VS, Kessler BM, Ploegh HL. December 2003. "A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L." Journal of Biological Chemistry 278(51): 51841-50.*

Li YJ, Oliveira SA, Xu P, Martin ER, Stenger JE, Scherzer CR, Hauser MA, Scott WK, Small GK, Nance MA, Watts RL, Hubble JP, Koller WC, Pahwa R, Stern MB, Hiner BC, Jankovic J, Goetz CG, Mastaglia F, Middleton LT, Roses AD, Saunders AM, Schmechel DE, Gullans SR, Haines JL, Gilbert JR, Vance JM, Pericak-Vance MA. December 2003. "Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease Human Molecular Genetics." Human Molecular Genetics 12: 3259-67.*

Stein RL. December 2003. "High-Throughput Screening in Academia: The Harvard Experience." The Journal of Biomolecular Screening 8(6): 615-9.*

November

Kocks C, Maehr R, Overkleeft HS, Wang EW, Lyer LK, Lennon-Dumenil AM, Ploegh HL, Kessler BM. November 2003. "Functional Proteomics of the Active Cysteine Protease Content in Drosophila S2 Cells." Molecular & Cellular Proteomics 2(11): 1188-97.*

October

Chun SJ, Rasband MN, Sidman RL, Habib AA, Vartanian T. 27 October 27, 2003. "Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelination." Journal of Cell Biology 163(2): 397-408.*

Scherzer C. October 1, 2003. "Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease." Molecular Genetics 12(9): 2457-66. Electronically published August 5, 2003.*

Yoshimura S, Teramoto T, Whalen MJ, Irizarry MC, Takagi Y, Qiu J, Harada J, Waeber C, Breakefield XO, Moskowitz MA. October 2003. "FGF-2 regulates neurogenesis and degeneration in the dentate gyrus after traumatic brain injury in mice." Journal of Clinical Investigation 112(8): 1202-10.

Xing X, Ho P, Bourquin G, Yeh LA, Cuny GD. October 2003. "Synthesis, Stereochemistry Confirmation and Biological Activity Evaluation of a Constituent from Isodon excisus." Tetrahedron 59(50): 9961-9.*

Goldberg MS, Fleming SM, Palacino JJ, Cepeda C, Lam HA, Bhatnagar A, Meloni EG, Wu N, Ackerson LC, Klapstein GJ, Gajendiran M, Roth BL, Chesselet MF, Maidment NT, Levine MS, Shen J. October 2003. "Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons." Journal of Biological Chemistry 278: 43628-35.*

September

Leissring MA, Condron MM, Teplow DB, Stein RL, Farrris W, Selkoe DJ. September 26, 2003. "Kinetics of amyloid b-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays." Journal of Biological Chemistry 278(39): 37314–20.*

Wong STC, Tjandra D, Wang H, Shen W. September 2003. "Workflow-Enabled Distributed Component-Based Information Architecture for Digital Medical Imaging Enterprises." IEEE Transactions on Information Technology in Biomedicine 7: 171-83.*

Cuny GD. September 2003. "Intramolecular ortho-arylation of phenols utilized in the synthesis of the aporphine alkaloids (±)-lirinidine and (±)-nuciferine." Tetrahedron Letters 44: 8149-52.*

Xing X, Padmanaban D, Yeh LA, Cuny GD. September 2003. xing_xuechao_sep_2002"Utilization of a copper-catalyzed diaryl ether synthesis for the preparation of verbenachalcone." Tetrahedron 58(39): 7903-10.*

Liu Y, Lashuel H, Choi S, Xing X, Case A, Ni J, Yeh LA, Cuny GD, Stein RL, Lansbury PT. September 2003. "Discovery of Inhibitors That Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line." Chem Biology 10(9): 837-46.*

August

Sanders AJ, Bertram L, Mullin K, Sampson AJ, Latifzai K, Basu S, Jones J, Kinney D, MacKenzie-Igano L, Yu S, Albert MS, Moscarillo TJ, Go RCP, Bassett SS, Daly MJ, Laird NM, Wang X, Velicelebi G, Wagner SL, Becker DK, Tanzi RE, Blacker D. August 28, 2003. "Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin." Human Molecular Genetics 12(21): 2765-76.*

Xie Z, Sanada K, Samuels BA, Shih H, Tsai L. August 22, 2003. "Serine 732 Phosphorylaton of FAK by Cdk5 Is Important for Microtubule Organization, Nuclear Movement, and Neuronal Migration." Cell 114: 469-82.*

Case A, Stein RL. August 12, 2003. "Kinetic analysis of the action of tissue transglutaminase on peptide and protein substrates." Biochemistry 42(31): 9466-81.

July

Zhai Q, Wang J, Kim A, Liu Q, Watts R, Hoopfer E, Mitchison T, Luo L, He Z. July 17, 2003 "Involvement of the Ubiquitin-Proteasome System in the Early Stages of Wallerian Degeneration." Neuron 39: 217-25.

Lehnardt S, Massillon L, Follett P, Jensen FE, Ratan R, Rosenberg PA, Volpe JJ, Vartanian T. July 8, 2003. "Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway." Proceedings of the National Academy of Sciences, USA 100(14): 8514-9.*

Isacson O. July 2003. "The production and use of cells as therapeutic agents in neurodegenerative diseases." The Lancet 2: 417-24.*

Zhou T, Aumais JP, Liu X, Yu-Lee L, Erikson RL. July 2003. "A Role for Plk1 Phosphorylation of NudC in Cytokinesis." Developmental Cell 5: 127-38.

June

El Khoury JB, Leung J. June 16, 2003. "CD36 Mediates the Innate Host Response to beta-Amyloid." The Journal of Experimental Medicine 197(12): 1657-66.*

Bertram L, Blacker D, Saunders AJ, Tanzi RE. June 2003. "No association between marker D10S1423." Molecular Psychiatry 8(6): 571-3.*

Campbell WA, Wolfe MS, Xia W. June 2003. "Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase." Journal of Neurochemistry 85: 1563-74.*

Wang S, Petravicz J, Breakefield XO. June 2003. "Single HSV-Amplicon Vector Mediates Drug-Induced Gene Epression via Dimerizer System." Molecular Therapy 7(6): 790-800.

May

Davidson BL, Breakefield XO. May 2003. "Viral vectors for gene delivery to the nervous system." Nature Reviews Neuroscience 4(5): 353-64.

April

Chen C, Regehr WG. April 15, 2003 "Presynaptic Modulation of Retinogeniculate Synapse." Journal of Neuroscience 23(8): 3130-5.

Lee K, Kohane IS, Butte A. April 12, 2003. "PGAGENE: Integrating Quantitative Gene-specific Results from the NHLBI Programs for Genomic Applications." Bioinformatics 19(6): 778-9.*

Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ and Guénette S. April 1, 2003. “Insulin-degrading enzyme regulates the levels of insulin, amyloid ß-protein, and the ß-amyloid precursor protein intracellular domain in vivo.” Proceedings of the National Academy of Sciences, USA 100(7): 4165-7.

Allan D, St. Pierre S, Miguel-Aliaga I, Thor S. April 2003. "Specification of Neuropeptide Cell Identity by the Integration of Retrograde BMP Signaling and a Combinatorial Transcription Factor Code." Cell 113: 73-86.

Case A, Stein RL. April 2003. "Enzymatic reaction of silent substrates: kinetic theory and application to the serine protease chymotrypsin." Biochemistry 42(16): 4727-32.*

March

Case A, Stein RL. March 2003. "Mechanistic origins of the substrate selectivity of serine proteases." Biochemistry 42(11): 3335-48.*

Stein RL. March 2003. "A New Model for Drug Discovery--Meeting our Societal Obligation." Drug Discovery Today 8(6): 245-8.*

Basu C, Kravitz E. March 2003. "Morphology and monoaminergic modulation of Crustacean Hyperglycemic Hormone-like immunoreactive neurons in the lobster nervous system." Journal of Neurocytology 32(2): 253-63.*

January

Isacson O, Bjorklund LM, Schumacher JM. January 2003. "Toward Full Restoration of Synaptic and Terminal Function of the Dopaminergic System in Parkinson's Disease by Stem Cells." Annals of Neurology 53(S3): S135-48.