2006 - 2005 Publications Archive
*Published with acknowledgment of Harvard Neurodiscovery Center (formerly the Harvard Center for Neurodegeneration & Repair or "HCNR") resources.
2006
December
Luchansky SJ, Lansbury PT Jr, Stein RL. December 12, 2006 "Substrate recognition and catalysis by UCH-L1." Biochemistry 45(49): 14717-25.*
Lee Th, Seng S, Avraham H, Li H, Kennel S, Avraham S. December 29, 2006. "Integrin regulation by vascular endothelial Growth Factor in human brain mucrovascular endothelial cells: Role of alpha6 in angiogenesis." Journal of Biological Chemistry 281: 40450-60.
November
Seng S, Avraham H, Jiang S, Venkatesh S, Li H, Avraham S. November 2006. "KLHL1/MRP2 Mediates Neurite Outgrowth in a Glycogen Synthase Kinase 3B-Dependent Manner." Molecular and Cellular Biology 26(22): 8371-84.
Ozdinler PH, Macklis JD. November 2006. "IGF-I specifically enhances axon outgrowth of corticospinal motor neurons." Nature Neuroscience 9(11): 1371-81. Electronically published October 22, 2006.*
Peled S, Friman O, Jolesz F, Westin CF. November 2006. "Geometrically constrained two-tensor model for crossing tracts in DWI." Magnetic Resonance Imaging 24(9): 1263-70. Electronically published September 12, 2006.*
October
Broom WJ, Auwarter KE, Ni J, Russel DE, Yeh LA, Maxwell MM, Glicksman MA, Kazantsev AG, Brown RH jr. October 11, 2006. "Two Approaches to Drug Discovery in SOD1-Mediated ALS." Journal of Biomolecular Screening 11(7): 729-35. Electronically published August 23, 2006.*
Ingelsson M, Ramasamy K, Cantuti-Castelvetri I, Skoglund L, Matsui T,
Orne J, Kowa H, Raju S, Vanderburg CR, Augustinack JC, de Silva R, Lees
AJ, Lannfelt L, Growdon JH, Frosch MP, Standaert DG, Irizarry MC, Hyman
BT. October 2006. "No alteration in tau exon 10 alternative splicing in tangle-bearing neurons of the Alzheimer's disease brain." Acta Neuropathol 112(4): 439-49. Electronically published June 27, 2006.
September
Isaacs AM, Senn DB, Yuan M, Shine JP, Yankner BA. September 22, 2006. "Acceleration of Amyloid beta-Peptide Aggregation by Physiological Concentrations of Calcium." Journal of Biological Chemistry 281(38): 27916-23. Electronically published June 26, 2006.*
Cortes ML, Oehmig A, Perry KF, Sanford JD, Breakefield XO. September 7, 2006. "Expression of human ATM mutated cDNA in Atm-deficient mouse brain mediated by HSV-1 amplicon vector." Neuroscience 141(3): 1247-56. Electronically published June 30, 2006.*
August
Meier DS, Guttmann CR. August 15, 2006. "MRI time series modeling of MS lesion development." Neuroimage 32(2): 531-7. Electronically published June 27, 2006.*
Bandyopadhyay S, Ni J, Ruggiero A, Walshe K, Rogers MS, Chattopadhyay N, Glicksman MA, Rogers JT. August 2006. "A High-Throughput Drug Screen Targeted to the 5'Untranslated Region of Alzheimer Amyloid Precursor Protein mRNA." Journal of Biomolecular Screening 11(5): 469-80. Electronically published April 28, 2006.*
July
Liu G, Huang W, Moir RD, Vanderburg CR, Lai B, Peng Z, Tanzi RE, Rogers JT, Huang X. July 2006. "Metal exposure and Alzheimer's pathogenesis." Journal of Structural Biology 155(1): 45-51. Electronically published February 9th, 2006.*
May
Boston-Howes W, Gibb SL, Williams EO, Pasinelli P, Brown RH Jr, Trotti D. May 19, 2006. "Caspase-3 cleaves and inactivates the glutamate transporter EAAT2." Journal of Biological Chemistry 281(20): 14076-84. Electronically published March 27, 2006.*
Zeng WQ, Gao H, Brueton L, Hutchin T, Gray G, Chakrapani A, Olpin S, Shih VE. May 1, 2006. "Fumarase deficiency caused by homozygous P131R mutation and paternal partial isodisomy of chromosome 1." American Journal of Medical Genetics Part A 140(9): 1004-9.*
Brown MD, Sacks DB. May 2006. "IQGAP1 in cellular signaling: bridging the GAP." Trends in Cell Biology 16(5): 242-9. Electronically published April 3, 2006.
April
Kumar S, Savitz S, Schlaug G, Caplan L, Selim M. April 25, 2006. "Antiplatelets, ACE inhibitors, and statins combination reduces stroke severity and tissue at risk." Neurology 66(8): 1153-8.*
Nicholson MJ, Moradi B, Seth NP, Xing X, Cuny GD, Stein RL, Wucherpfennig KW. April 1, 2006. "Small molecules that enhance the catalytic efficiency of HLA-DM." Journal of Immunology 176(7): 4208-20.*
Zhou X, Cao XH, Perlman Z, Wong STC. April 2006. "A computerized cellular imaging system for high content analysis in Monastrol suppressor screens." Journal of Biomedical Informat 39(2): 115-25. Electronically published June 22, 2005.
March
Tkatchenko AV, Walsh PA, Tkatchenko TV, Gustincich S, Raviola E. March 21, 2006. "Form deprivation modulates retinal neurogenesis in primate experimental myopia." Proceedings of the National Academy of Sciences, USA 103(12): 4681-6.*
Shaw GC, Cope JJ, Li L, Corson K, Hersey C, Ackermann GE, Gwynn B, Lambert AJ, Wingert RA, Traver D, Trede NS, Barut BA, Zhou Y, Minet E, Donovan A, Brownlie A, Balzan R, Weiss MJ, Peters LL, Kaplan J, Zon LI, Paw BH. March 2, 2006. "Mitoferrin is essential for erythroid iron assimilation." Nature 440(7080): 96-100.*
Becker EB, Bonni A. March 2, 2006. "Pin1 mediates neural-specific activation of the mitochondrial apoptotic machinery." Neuron 49(5): 655-62.
February
Steele AD, Emsley JG, Özdinler PH, Lindquist S, Macklis JD. February 28, 2006. "Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis." Proceedings of the National Academy of Sciences, USA 103: 3416-21.*
Case A, Stein RL. February 21, 2006. "Mechanistic studies of ubiquitin C-terminal hydrolase L1." Biochemistry 45(7): 2443-52.*
Khurana V, Lu Y, Steinhilb ML, Oldham S, Shulman JM, Feany MB. February 7, 2006. "TOR-Mediated Cell-Cycle Activation Causes Neurodegeneration in a Drosophilia." Current Biology 16(3): 230-41.*
Kraves S, Weitz CJ. February 2006. "A role for cardiotrophin-like cytokine in the circadian control of mammalian locomotor activity." Nature Neuroscience 9(2): 212-9.*
January
Portmann-Lanz C, Schoeberlein A, Huber A, Sager R, Malek A, Holzgreve W, Surbek D. January 25, 2006. "Placental mesenchymal stem cells as potential autologous graft for pre- and perinatal neuroregeneration." American Journal of Obstetrics and Gynecology 194(3): 664-73.
Ancuta P, Kunstman KJ, Autissier P, Zaman T, Stone D, Wolinsky SM, Gabuzda D. January 20, 2006. "CD16+ monocytes exposed to HIV promote highly efficient viral replication upon differentiation into macrophages and interaction with T cells." Virology 344(2): 267-76.*
Robbins EM, Betensky RA, Domnitz SB, Purcell SM, Garcia-Alloza M, Greenberg C, Rebeck GW, Hyman BT, Greenberg SM, Frosch MP, Bacskai BJ. January 11, 2006. "Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease." Journal of Neuroscience 26(2): 365-71.*
Gurol ME, Irizarry MC, Smith EE, Raju S, Diaz-Arrastia R, Bottiglieri T, Rosand J, Growdon JH, Greenberg SM. January 10, 2006. "Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy." Neurology 66(1): 23-9.
Shu T, Tseng H, Sapir T, Stern P, Zhou Y, Sanada K, Fischer A, Coquelle F, Reiner O, Tsai L. January 5, 2006 "Doublecortin-like Kinase Controls Neurogenesis by Regulating Mitotic Spindles and M Phase Progression." Neuron 49(1): 25-39.*
2005
December
Bianchetta MJ, Betensky RA, Cohen JB. December 13, 2005. "Cell-Surface MuSK Self-Association: a Crucial Role for the Putative Signal Sequence." Biochemistry 44(49): 16229-38.
Ferrante KL, Shefner J, Zhang H, Betensky R, O'Brien M, Yu H, Fantasia M, Taft J, Beal MF, Traynor B, Newhall K, Donofrio P, Caress J, Ashburn C, Freiberg B, O'Neill C, Paladenech C, Walker T, Pestronk A, Abrams B, Florence J, Renna R, Schierbecker J, Malkus B, Cudkowicz M. December 13, 2005. "Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS." Neurology 65(11): 1834-6.
Fischer A, Sananbenesi F, Pang P, Lu B, Tsai L. December 5, 2005. "Opposing Roles of Transient and Prolonged Expression of p25 in Synaptic Plasticity and Hippocampus-Dependent Memory." Neuron 48(5): 825-38.
Cerca N, Martins S, Sillankorva S, Jefferson KK, Pier GB, Oliveira R, Azeredo J. December 2005. "Effects of growth in the presence of subinhibitory concentrations of dicloxacillin on Staphylococcus epidermidis and Staphylococcus haemolyticus biofilms." Applied and Environmental Microbiology 71(12): 8677-82.
November
Cantuti-Castelvetri I, Lin MT, Zheng K, Keller-McGandy CE, Betensky RA, Johns DR, Beal MF, Standaert DG, Simon DK. November-December 2005. "Somatic mitochondrial DNA mutations in single neurons and glia." Neurobiology of Aging 26(10): 1343-55. Electronically published December 29, 2004.*
Teng X, Degterev A, Jagtap P, Xing X, Choi S, Denu R, Yuan J, Cuny GD. November 15, 2005. "Structure-activity relationship study of novel necroptosis inhibitors." Bioorganic and Medicinal Chemistry Letters 15(22): 5039-44*
Huang L, Chen D, Liu D, Yin L, Kharbanda S, Kufe D. November 15, 2005. "MUC1 oncoprotein blocks glycogen synthase kinase 3beta-mediated phosphorylation and degradation of beta-catenin." Cancer Research 65(22): 10413-22.
Hemming ML, Selkoe D. November 11, 2005. "Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor." Journal of Biological Chemistry 280(45): 37644-50.*
Irizarry MC, Gurol ME, Raju S, Diaz-Arrastia R, Locascio JJ, Tennis M, Hyman BT, Growdon JH, Greenberg SM, Bottiglieri T. November 8, 2005. "Association of homocysteine with plasma amyloid beta protein in aging and neurodegenerative disease." Neurology 65(9): 1402-8.
Puopolo M, Bean BP, Raviola E. November 2005. "Spontaneous activity of isolated dopaminergic periglomerular cells of the main olfactory bulb." Journal of Neurophysiology 94(5): 3618-27.
LaVoie MJ, Ostaszewski BL, Weihofen A, Schlossmacher MG, Selkoe D. November 2005. "Dopamine covalently modifies and functionally inactivates parkin." Nature Medicine 11(11): 1214-21. Electronically published *
October
Kokoeva MV, Yin H, Flier JS. October 28, 2005. "Neurogenesis in the hypothalamus of adult mice: potential role in energy balance." Science 310(5748): 679-83*
D'Souza GG, Boddapati SV, Weissig V. October 2005. "Mitochondrial leader sequence-plasmid DNA conjugates delivered into mammalian cells by DQAsomes co-localize with mitochondria." Mitochondrion 5(5): 352-8.
September
Stark PRH, Halleck AE, Larson DN. September 29, 2005. "Short order nanohole arrays in metals for highly sensitive probing of local indices of refraction as the basis for a highly multiplexed biosensor technology." Methods 37: 37-47.
Kirsch HE, Walker JA, Winstanley FS, Hendrickson R, Wong STC, Barbaro N, Laxer KD, Garcia PA. September 13, 2005. "Limitations of Wada memory asymmetry as a predictor of outcomes after temporal lobectomy." Neurology 65(5): 676-80.*
Rosand J, Muzikansky A, Kumar A, Wisco JJ, Smith EE, Betensky RA, Greenberg SM. September 2005. "Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy." Annals of Neurology 58(3): 459-62.*
The International Multiple Sclerosis Genetics Consortium. September 2005. "A high-density screen for linkage in Multiple Sclerosis." American Journal of Human Genetics 77(3): 454-67. Electronically published July 29, 2005.*
August
Scholz J, Broom DC, Youn DH, Mills CD, Kohno T, Suter MR, Moore KA, Decosterd I, Coggeshall RE, Woolf CJ. August 10, 2005. "Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury." Journal of Neuroscience 25(32): 7317-23.
Soni S , Dhawan S, Rosen KM, Chafel, M, Chishti AH, Hanspal M. August 9, 2005. "Characterization of events preceding the release of malaria parasite from host red blood cell." Blood Cells, Molecules, and Diseases 35(2): 201-11.*
DeMasi J, Huh KW, Nakatani Y, Munger K, Howley PM. August 9, 2005. "Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding." Proceedings of the National Academy of Sciences, USA 102(32): 11486-91.
Wang J, Zhai Q, Chen Y, Lin E, Gu W, McBurney MW, He Z. August 1, 2005. "A local mechanism mediates NAD-dependent protection of axon degeneration." Journal of Cell Biology 170(3): 349-55.
July
Park SK, Nguyen MD, Fischer A, Luke MP, Affar el B, Dieffenbach PB, Tseng HC, Shi Y, Tsai LH. July 29, 2005. "Par-4 links dopamine signaling and depression." Cell 122(2): 153-5.
Tseng HC, Ovaa H, Wei NJC, Ploegh H, Tsai LH. July 22, 2005. "Phosphoproteomic analysis with a solid-phase capture-release-tag approach." Chemistry & Biology 12: 769-77.*
Sanada K, Tsai L. July 15, 2005. "G Protein beta gamma Subunits and AGS3 Control Spindle Orientation and Asymmetric Cell Fate of Cerebral Cortical Progenitors." Cell 122(1): 119-31.*
Ahn JS, Radhakrishnan ML, Mapelli M, Choi S, Tidor B, Cuny GD, Musacchio A, Yeh LA, Kosik KS. July 2005. "Defining Cdk5 Ligand Chemical Space with Small Molecule Inhibitors of Tau Phosphorylation." Chemistry & Biology 12: 811-23*
Zeng WQ, Al-Yamani E, Acierno JS Jr, Slaugenhaupt S, Gillis T, MacDonald ME, Ozand PT, Gusella JF. July 2005. "Biotin-responsive basal ganglia disease maps to 2q36.3 and is due to mutations in SLC19A3." American Journal of Human Genetics 77(1): 16-26.*
Mendez I, Sanchez-Pernaute R, Cooper O, Viñuela A, Ferrari D, Björklund L, Dagher A, Isacson, O. July 2005. "Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease." B128 (Pt 7): 1498-510. Electronically published May 4, 2005.*
Lee J, Fukumoto H, Orne J, Klucken J, Raju S, Vanderburg CR, Irizarry MC, Hyman BT, Ingelsson M. July 2005. "Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms." Experimental Neurology 194(1): 91-6.*
June
Chung CY, Seo H, Sonntag KC, Brooks A, Lin L, Isacson, O. June 1, 2005. "Cell type specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection." Human Molecular Genetics 14(13): 1709-25. Electronically published May 11, 2005.*
Jefferson KK, Goldmann DA, Pier GB. June 2005. "Use of confocal microscopy to analyze the rate of vancomycin penetration through Staphylococcus aureus biofilms." Antimicrobial Agents Chemotherapy 49(6): 2467-73.*
May
Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny G, Mitchison T, Moskowitz M, Yuan J. May 29, 2005. "Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury." Nature Chemical Biology 1: 112-9.*
Ikeda T, Kimura F, Nakata Y, Sato K, Ogura K, Motoyoshi K, Sporn M, Kufe D. May 2005. "Triterpenoid CDDO-Im downregulates PML/RARalpha expression in acute promyelocytic leukemia cells." Cell Death & Differentiation 12(5): 523-31.
April
Cowan CW, Shao YR, Sahin M, Shamah SM, Lin MZ, Greer PL, Gao S, Griffith EC, Brugge JS, Greenberg ME. April 21, 2005. "Vav family GEFs link activated Ephs to endocytosis and axon guidance." Neuron 46(2): 205-17.
Farris W, Leissring MA, Hemming ML, Chang AY, Selkoe DJ. April 7, 2005 "Alternative splicing of human insulin-degrading enzyme yields a novel isoform with decreased ability to degrade insulin and amyloid ß-protein." Biochemisty 44(17): 6513-25.
Duval E, Case A, Stein RL, Cuny GD. April 1, 2005. "Structure-activity relationship study of novel tissue transglutaminase inhibitors." Bioorganic and Medicinal Chemistry Letters 15(7): 1885-9.*
March
Case A, Ni J, Yeh LA, Stein RL. March 15, 2005. "Development of a mechanism-based assay for tissue transglutaminase-results of a high-throughput screen and discovery of inhibitors." Analytical Biochemistry 338(2): 237-44.*
Ray SS, Nowak RH, Lansbury PT. March 8, 2005. "Small-molecule-mediated stabilization of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants against unfolding and aggregation." Proceedings of the National Academy of Sciences, USA 102(10): 3639-44.*
February
Yeh LA, Padmanaban D, Ho P, Xing X, Rowley P, Morse LJ, Jensen RV, Cuny GD. February 15, 2005. "Effects of a verbenachalcone derivative on neurite outgrowth, inhibition of caspase induction and gene expression." Bioorganic and Medicinal Chemistry Letters 15(4): 1193-6.*
Bakshi P, Liao YF, Gao J, Ni J, Stein R, Yeh LA, Wolfe MS. February 2005. "A high-throughput screen to identifiy inhibitors of Amyloid beta-protein precursor processing." Journal of Biomolecular Screening 10: 1-12.*
Standaert DG. February 2005. "Applications of Laser Capture Microdissection in the Study of Neurodegenerative disease." Archives of Neurology 62(2): 203-5.
Carterson AJ, Honer zu Bentrup K, Ott CM, Clarke MS, Pierson DL, Vanderburg CR, Buchanan KL, Nickerson CA, Schurr MJ. February 2005. "A549 lung epithelial cells grown as three-dimensional aggregates: alternative tissue culture model for Pseudomonas aeruginosa pathogenesis." Infection and Immunity 73(2): 1129-40.
January
Zucker B, Luthi-Carter R, Kama JA, Dunah AW, Stern EA, Fox JH, Standaert DG, Young AB, Augood SJ. January 15, 2005. "Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington's disease: Neuronal selectivity and potential neuroprotective role of HAP1." Human Molecular Genetic 14(2): 179-89.